• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    1,2,4-triazol-(5)-yl-[thio] phosphates are disclosed having the formula <IMAGE> wherein R1=alkyl with from 1 to 5 carbon atoms; R2=OR1, R1, C6H5, NHR1, N(R1)2; X=O, S R3=H, alkyl with from 1 to 5 carbon atoms, C6H5, benzyl, alkenyl with from 2 to 6 carbon atoms, alkynyl with from 2 to 6 carbon atoms; and R4=vinyl, halovinyl, polyhalovinyl, vinyl substituted with aryl groups, alkyl groups with from 1 to 4 carbon atoms, O-alkyl groups with from 1 to 4 carbon atoms, S-alkyl groups with from 1 to 4 carbon atoms; haloalkyl, acetyl, cyclohexenyl, benzoyl <IMAGE> <IMAGE> OR1, N(R1)2, NHR1], +TR <IMAGE> Also disclosed are 1,2,4-triazole intermediates having the formula <IMAGE> wherein: X, R3 and R4 have the same meanings as indicated above. The phosphate esters are useful in combatting infestations of pests such as orthoptera, aphides, diptera, lepidoptera, coleoptera, acari, nematodes.
    公开号:SU795485A3
    申请号:SU772541750
    申请日:1977-11-16
    公开日:1981-01-07
    发明作者:Гоццо Франко；Марино Босчи Пьер；Лонгони Анжело
    申请人:Монтэдисон С.П.А. (Фирма)；
    IPC主号:
    专利说明:

    one
    The invention relates to the field of chemistry of organophosphorus compounds, namely to the method of producing new, triazole-containing esters of phosphoric acids of general formula I
    Bo s and xp
    2 /
    And - E
    R 1
    3
    where R g alkyl,
    R is ethyl, phenyl, alkoxygroup. With Cz or dimethyl amino group, R is alkyl or phenyl, R is vinyl, halo vinyl, polyhaloxy, vinyl substituted with C-Cd alkyl, phenyl, S-alkyl group C-C4 or alkoxy C - C4;
    1-bxy-2-thiomethylethyl, carbalkoxyethyl, CO — CH2-SR group, acetyl, benzoyl, 1-chlorocyclohexenyl or group
    -CH-K% where, ОV, S-RlNCll / g, dHj
    / xO 0-C-R, -0-C- / 7D w
     ABOUT . . . g aloideoyl or -O-d - haloalmyl, possessing insecticidal, nematicidal and acaricidal activity. "
    The triazole-containing phosphate esters of Q. acids of formula 1 are new and 3 are not described in the literature.
    Of the triazole-containing phosphoric acid esters, 0,0-diethyl (1-isopropyl-5-chloro-1, 2,4-triazol-3-yl) thiophosphate (Miral (R)) is known, which is about 5% effective against soil insects l.
    A known method for producing a triazole-containing ester of diethylthiophos, a formic acid of the formula
    0
    K; SbN5
    ((12H50) 2P-OCH

    5 OHZ
    five
    by reacting 1-phenyl-3-methyl .5-triazol-5-one with potassium carbonate and copper powder in the medium, methyl ethyl ketone, followed by treatment of the resulting product with acid chloride
    | 0, C) -diethylthiophosphoric acid at 60 ° C 2.
    However, the triazole-containing thiophosphoric acid esters of the formula I were not obtained by this method.
    The aim of the invention is to develop a process for the preparation of the thiazole-containing thiophosphoric acid esters of the formula 1.
    The goal has been achieved by the described method for preparing the triazole-containing thiophosphoric acid esters of formula 1, namely, that the alkali metal salt IR-3-R -1,2,4-triazol-5-it is reacted with thiophosphoric acid chloride in an inert solvent at a temperature of 55 ° C.
    The compounds of formula 1 possess a wide range of insecticidal action, since they are effective in combating orthoptera, aphids, diptera, coleopters, lepidopterans, and also have acaricidal and nematocidal effects, while being slightly toxic to non-blooded animals.
    The starting compound for the preparation of 5-hydroxy-1,2,4-triazole derivatives in which the R is a phenyl group is an oC-chloro- ", substituted formylidenephenyl hydrazine, which is treated with ammonia, followed by condensation of the amine derivative with phosgene or thiophosgene. As a result, thiazoles are formed, which in an alkaline medium give salts. In cases where K contains functional groups, various reactions can be used to introduce other groups into the triazolone side chain. Thus, from 1-phenyl 3-acetyl-1, 2,4-triazol-5-one, due to the specific properties of acetyl groups, by reduction of the CO groups, the corresponding alcohols are obtained, which, after treatment with thionyl chloride, are used to prepare compounds of formula 1.
    Triazoles, in which R is alkyl, are obtained by condensation of aldehyde with 2-alkyl semicarbaeid, and then the semicarbazone thus obtained is treated with bromine in glacial acetic acid, resulting in a triazole, which is in turn treated in an alkaline medium.
    It has been established that if R represents a vinyl group, then after treatment with bromine, it is possible to carry out the sequence of addition and cleavage reactions: - .. In particular, when halogen atoms, but not bromine, are present in the starting aldehyde in the / 5 position, they can be replaced by bromine atoms in the process of cyclization.
    Depending on the temperature conditions, the prevailing direction of the reaction may be the formation of a single cyclization product containing the same halo-vinyl groups, such as THAT AND the original aldehyde or mixtures of products containing bromine atoms in the vinyl groups of thiazole derivatives.
    Vinyl groups in position
    Q 3,1-phenyl-1,2,4-triazole-5-one can be introduced by a reaction, the starting compound for which is 1-phenyl-3-acetyl-1,2,4-triazole 5-one, flowing by acetyl groups.
    5 In addition, it was also established that the cyclization of the common semicarbazones, of the formula
    R -dH N-T5-e -i3H2
    U to o
    3 d
    where R and R have the indicated meanings, can be carried out in the presence of ferric chloride;
    5 The described cyclization reaction allows the direct preparation of a high purity triazole. even in those cases when the group R contains double olefinic bonds, according to which bromine is added, and thus has advantages over the other methods described above.
    The reaction is carried out in a polar-5 about solvent, preferably in acetic acid, at a temperature / boiling point.
    The main characteristics of 1,2,4triazol-5-ones, obtained by one of the described methods, are presented in tal.
    In the presence of a base, the 1,2,4-triazol-5 -ones are converted to alkali metal salts, which, by reacting with the corresponding chlorine 5 thiophosphoric acid hydride, form triazole-containing thiophosphoric esters. acids of formula 1.
    The resulting compounds of formula 1 are shown in Table 2. 0
    Example. Preparation of 1-phenyl 3-acetyl-1-2-4-triazole-5-one.
    80 (lp of aqueous 32% ammonia solution (1.32 mol) poured 500 ml
    5 ethanol, a solution of 60 g (0.305 mol) of ci-chloro-ct-acetyl formylidenephenylhydrazine is added in small portions to this solution. After the introduction of the reagents is completed, the mixture is stirred for 2 hours at room temperature. Undissolved ob-amin6-c6-acetyl formylidenephenylhydrazn. (2) (48 g) filtered and ppfmy-. Add 200 ml of water (yellow precipitate, mp. 182-184s).
    42.5 g (0.24 mole) d. α-amino-sabacetyl formylidenephenylhydrazine is suspended in 300 ml of benzene, 57 ml (O, 72 mol) of pyridine are added to the suspension, and then 40 ml of benzene, a phosgene solution of 10% (w / v, 0.36 mol) are added dropwise maintaining the temperature 15-20 ° C.
    After the end of the introduction of the reagent, the mixture is stirred for 30 minutes at room temperature, and then 100 ml of water and 10 lym of concentrated hydrochloric acid are added to it. The mixture is stirred at room temperature for another 2 hours. The non-soluble precipitate is filtered through a porous diaphragm and washed with water. The yield is 1-phenyl-3-acetyl-1,2,4-triazole 5-one. And 25 g, (t.p. .174-176 ° C. :)
    Examples 2-4. The method described in: Example, starting from ot-chloro-C-benzoyl formylidenephenylhydrazine, gives 1-phenyl-3-benzoyl-1,2,4triazol-5-one.
    Starting from ci-chloro-cL-methylthioacetyl formylidenephenylhydrazine, 1-phenyl-3- (methylthioacetyl71, 2,4-triazol-5-one) is obtained.
    Starting from oi, -chloro-c-carboethoxy formylidenephenylhydrazine, 1-phenyl-3 - (carboxyethyl) -1,2,4, 4, triazole 5-one is obtained.
    EXAMPLE 5. Preparation of 1-phenylE- (1-hydroxy-2-methylmercapto) ethyl-1,2,4triazol-5-one.
    To 2.3 g of 1-phenyl-3-methylthioacetyl1, 2,4-triazol-5-one suspended in 40 ml of methanol, a solution of O, 3 sodium borohydride in 5 ml of water is added dropwise. The reaction mixture is stirred for 1 h, then 0.5 ml of concentrated hydrochloric acid is added and the solvent is removed.
    The residue is mixed with 20 ml of water and 0.5 ml of concentrated hydrochloric acid, the aqueous layer is extracted with ethyl acetate (3 x 30 ml), and the organic layer is dried over anhydrous sodium sulfate.
    The solvent is distilled off under vacuum, and the solid residue is recrystallized from benzene (10 ml), resulting in 1 g of 1-phenyl-3- (1-hydroxy-2-methylmercapto) ethyl 1,2,4-triazol-5-one (residue ivory, mp 102-104 ° C).
    PRI me R, 6. Getting 1-phenyl 3 th-hydroxyethyl 1-1, 2,4-triazol-5-one.
    Following the procedure described in Example 5 and using 70 g of 1-phenyl-Zacetyl-1, 2,4-triazol-5-one as the starting compound, 56 g of 1-phenyl-3 (1-hydroxy-ethyl) 1 are obtained, 2,4triazol-5-one (mp. 149-150 s).
    PRI me R 7. Preparation of 1-phenyl-3-vinyl -1,2,4-triazol-5-one.
    To 16 g of the product obtained as described in Example B, dissolved in 350 ml of chloroform, 7.6 ml of thionyl chloride is added dropwise with stirring.
    The solution is stirred at room temperature for 2 hours and then mixed with 150 ml of water. The chloroform layer is separated and dried. After removal of the solvent, 17 g of 1-phenyl-3- (1-chloroethyl) -1,2,4-triazol-5-one are obtained (mp. 159-160 ° C).
    5.5 g thus obtained
    Product 0 is dissolved in 150 ml of benzene and dehydrochlorinated at low boiling conditions in the presence of 7.5 g of triethylamine. Immediately upon completion of the reaction, 10 ml of water and 10 ml of concentrated hydrochloric acid were introduced into the reaction mixture. The benzene layer is separated, washed with water and dried over anhydrous sodium sulfate. A part of the solvent was removed under vacuum until the solution volume was 50 ml. Upon cooling, 2 g of 1-phenyl-3-vinyl-1,2,4-triazol5-one (mp. 200 ° C) was isolated from the solution.
    Example Preparation of 1-methyl 5 3-tribromovinyl-1,3,4-triazol-5-one and 1-methyl (3) -c6-bromo-p, p-dichlorovinyl) 1,2,4-triazol-5-one.
    3 g (0.0153 mol) of 1- (p, | 3-dichlorocaprydene) -2-methyl semicarbazide
    0 is dissolved in 15 ml of glacial acetic acid, then 1.6 ml of bromine ((1.031 mol) is slowly added to this solution. The mixture is then heated (at a slight boil for
    5 30 minutes, cool and add 150 ml of water. The reaction mixture is extracted with ethyl acetate (50 ml x 2). The ethyl acetate extracts are washed with 50 ml of water and a saturated solution.
    0 sodium bicarbonate (40 ml x 3). It is then dried over anhydrous sodium sulphate, filtered and evaporated.
    W
    The residue obtained is mixed with
    5 to 50 ml of a 10% aqueous solution of sodium hydroxide and the entire mixture is heated to boiling. After that, the mixture is cooled and filtered. The filtrate is acidified.
    0 hydrochloric acid. A yellowish precipitate is formed, which is extracted with ethyl acetate (2 x 50 ml).
    The organic solution is then washed with water (50 ml), dried over anhydrous sodium sulfate and the solvent is distilled off. The result is 1.9 g of a yellowish precipitate, which is recrystallized from benzene (mp 161163 C). This product represents
    About a mixture of compounds, as evidenced by the results of mass spectrometry, according to which two molecular peaks of almost equal intensity were found (, 7 and M 273).
    5 Sample Preparation of 1-methyl 3-f, |% -dichlorovinyl) -1,2,4-triazol-5 on. 9.7 g (0.0494 mol) of 1 - (p, (i-dichloro acrylidene) -2-methylsemicarbaeid is diluted in 50 ml of glacial acetic acid. The solution is boiled, 2.8 ml is added dropwise (0.054 mol) bromine. At the end of the introduction of bromine, the solution is cooled. The acetic acid solution is slowly added dropwise to a suspension of 120 g of sodium bicarbonate in 300 ml of water. At the end of the rapid release of gases, 250 ml of ethyl acetate are added to the mixture and carefully the organic layer is separated, dried over anhydrous sodium sulfate and the solvent is partially evaporated as soon as the mixture has reached 40 ml, the evaporation is stopped and the solution is cooled to approximately 0 ° C. The precipitated precipitate is filtered off through a glass filter, resulting in 2 g of 1-methyl-3- (p, / -dichlorovinyl) -, 3.4 triazol-5-one (mp. 215-216 C after recrystallization from ethyl acetate). Examples 10-11. Using the corresponding 1- (polyhaloacrylidene) -2-methylsemicarbazide corresponding to the method of example 9, as the starting compound, the following 1 , 2,4triazol-5-ones: 1-methyl-3 (f, Jb-dibromovinyl) -1,2, triazol-5-one and 1-methyl-3- (tribromovinyl) -1,2,4-triazole- 5th And p and meer 12. Obtaining 1-methyl 3- (j, fi dichlorovinyl) -, 2,4-triazole-5on in the presence of ferric chloride. A solution of 49 g (0.18 mol) of ferric chloride hexahydrate in 100 ml of water is added to a solution of 17.5 g (0.089 mol) of 1- (ji, p | -dichloroacrylidene) 2-methylsemicarbazide in acetic acid (50 ml). The resulting solution is heated under cooling conditions for 3.5 hours. it is then allowed to spontaneously cool, then mixed with 150 ml of water. Then the solution is cooled to about 0 ° C (ice-water in a bath), resulting in 12 g of 1-methyl-3- (p, p-dichlorovinyl) -, 2,4-triazol-5-one (m.p. 215-21 ° C after recrystallization from ethyl acetate),. - Example 13: Preparation of 1-methyl 3- (p1, p-dimethylvinyl) -1,2,4-triazol5-one. To a solution of 10.6 g (0.119 mol) of 2-methylsemicarbazide in acetic acid (100 ml), 10 g (0.11 g1 mol) of p and p-dimethylacrolein are added dropwise. The reaction mixture is stirred at temperature 50c for 15 minutes and then a solution, 2 g (0.227) of MOL ferric chloride hexahydrate in 60 ml of water, is added to it. The whole mixture was stirred for 3 hours and then poured into 400 ml and extracted with ethyl acetate (2 x 150 ml), the organic layer was separated, washed with water and saturated sodium bicarbonate solution and dried over anhydrous sodium sulfate. . After removal of the solvent, 4 g of 1; -methyl-3- (p, p-dimethylvinyl) 1,2,4-tri-sol-5-one (mp 144-, 146 ° C) are obtained. Example 14. Preparation 1-methyl-3- (p-chloro-p-methoxyvinyl) -1,2,4triazol-5-one. In a round bottom flask equipped with a reflux condenser is placed. 6.8 g (0.035 mol) of 1-methyl-3 - (/ 3, p-dichlorovinyl) -1,2,4-triazol-5-one, 50 ml of methanol and 8 g of KOH. The reaction mixture is stirred at boiling point for 5 hours, then it is poured into water (150 MP), acidified with concentrated hydrochloric acid (20 ml) and extracted with ethyl acetate (3 x 10 ml). The organic layer is dried over anhydrous sodium sulfate, the solvent is removed and 3 g (1-methyl-3 (|% chloro-p-methoxyvinyl) -1,2,4-triazol-5-one) is obtained (mp. 198- 199c). EXAMPLE 15 Preparation of 1-methyl3- (2-chloro-1-cyclohexenyl) -1,2,4triazol-5-one. To a solution of 27 g (0.1 mol) of ferric chloride hexahydrate in 30 ml of water are added to 50 ml of acetic acid. The resulting solution is stirred at a temperature for 2 hours, a solution of 10.8 g (0.05 mol) of semicarbazone in 50 ml of acetic acid is added dropwise. The mixture is heated for another 1 hour. and then the solution is cooled and injected 3 After extraction with chloroform (2 x 200 ml), the chloroform extract is separated, washed with a saturated solution, sodium bicarbonate and dried over anhydrous sodium sulfate. After removing the solvent, 4.5 g of oily product are obtained. On standing oily, the product it solidifies and this solid is washed with diethyl ether, resulting in 4g of 1-methyl-3- (2-CHLOR-1-cyclohexenyl) -1,2,4-triazol-5-one (m.p. 183-185 ° C). According to the elemental analysis, the content of C1 in it is 16/76% versus the calculated 16.60%. Example 16. Obtaining 0,0-diethyl-0- (1-methyl-3-tribromovinyl-3riazolyl) thiophosphate. 3.82 g (0.01 mol) of 1-methylg3-tribromovinyl-5-hydroxy-1,2,4 sodium salt, riazole, is dissolved in 100 ml of acetone. 1.6 ml is added to this solution.
    (0.01 mol) of diethylthiophosphoric acid chloride. Then the solution is heated at a temperature of 55-60 ° C for 2 hours. After that, the acetone is added and the residue is dissolved in 100 ml of diethyl ether and 50 ml of water. The mixture is stirred. The organic layer was separated, dried over anhydrous sodium sulfate, and the solvent was evaporated. 4.7 g of a yellow oil are obtained, which is purified by chromatography on silica gel using benzene as eluent: yield of 0,0-diethyl-O- (1-ethyl-3-tribromovinyl 5-triazolyl) -tiophosphate 3.5 g (white crystalline substance (m.p. 45-50 ° C).
    In a similar way were obtained and other 0,0-diethyl-O-triazolylthiophosphates, are given in table 2
    Example17. Following the procedure described in Example 16 and using the sodium salt of 1-methyl-3 (/ 3, -dichlorovinyl) -5-oxy-1, 2,4-tripiazol, and 0.0dimethylchlorophosphate as the starting compounds, 0.0 is obtained. -dimethylthiophosphoric ether 1-methyl-3- (/ 3, /} - dichlorovinyl) -5-hydroxy-1,2 4-triazole. (mp. 102-103 C).
    Elemental analysis: C1 (theoretical). 22.3%, found 22.45%.
    EXAMPLE 18. Preparation of 1-methyl-3- (/, p-dichlorovinyl) -5-OXY-1,2,4-thiazole 0,0distiltiofosfat.
    1-Methyl; (p, p-dichlorovinyl) -1,2,4triazol-5-one (9, .15 g, 0.0466 mol) is suspended in acetone (150 ml). To this suspension is added KjCO (6.9 g, 0 , 05 mol) and 0,0-diethylthiophosphoric acid chloride (9.67 g, 0.0466 mol). The reaction mixture is stirred at 55-60 ° C for 2 hours, then filtered, and the solvent is removed and a yellow solid is obtained (16.7 g), which is recrystallized from hexane (250 ml). Thus, 11.3 g of product as a white solid, with a pl. 47-49 11 ::, the product yield after crystallization is 70%.
    The JK-spectrum of the product contains bands at 1538 and 1515 (triazole ring) and 1026 cm (-F-0-C- group.
    g. The purity of the compound was confirmed by thin layer chromatography (those) using benzene as a eluent and PdCl solution as a developer.
    Example19. Preparation of 1-motil-3- (Jb-methylvinyl) -5-hydroxy-1,2,, 4-triazole.
    1-Methyl-3- (|% -methylvinyl) -1,2,4-triazol-5-one (1.5 g. 0,0108 mol) is suspended in acetone (50 nl) and K-jCO (g , 0.013 mol) and 0.0diethylthiophosphoryl chloride (2.03 g, 0.0108 mol).
    The reaction mixture is stirred at a temperature of 55-60 ° C for 3 hours and then filtered. The solvent is removed to give a yellow oil (3.5 g), which is purified by chromatography on silica gel (40 g, benzene as eluent). 2.5 g of product are obtained in the form of a colorless oil, yield
    O purified, product 80%. The IR spectrum of the product contains absorption bands at 1520 (triazole ring) and 1020 cm (-P-0-C-group). The purity of the product is checked with
    5 using thin-layer chromatography (eluent benzene, the developer PdCl-j solution).
    Example 20. Evaluation of the biological activity of compounds.
    1) Biological effect on Macrosiphum enphorbiae (aphids).
    Sons of toglatov grown in pots infected with females
    5 aphids and after a few hours sprayed with a water dispersion of the compounds under study (see Table 5).
    The percentage of aphid mortality was assessed 24 hours after treatment (untreated plants 0).
    0
    2) Biological effect on Ріегisbrassisae (lepidoptera).
    Cut cawliflour leaves sprayed with aqueous dispersions of the products studied (see Table 5).
    five
    After drying, the leaves were infected with five-day caterpillars. The percentage of their mortality was determined 48 hours after treatment (untreated leaves 0).
    0
    3) Biological effect on Zeptinotarsa decemlineata (coleopter).
    Small tomato seedlings grown in pots were infected with four-day caterpillars, and then sprayed with aqueous dispersions of the products studied (see tab. 4 and. 5). The percentage of mortality (small untreated seedlings 0) was determined 48 hours after treatment.
    O
    4) Biological effect on C lex pip tens (dipter). Three-and four-day larvae were placed in two glasses with aqueous dispersions of the studied products (see Tables 4 and 5).
    5 mosquitoes. The percentage of mortality of the larvae (glasses with pure water 0) was determined 24 hours after treatment. 5) Biological effect on adults l etranychus urticae (ticks).
    0
    Pieces of the leaves of legumes were infected by adults with mites, and then treated with water dispersions of the studied compounds (see Tables 4 and 5). The percentage of mortality is determined
    24 hours after treatment (untreated leaves, mortality 0).
    6). Biological effect on Fetranychuc igticae 1 (ticks).
     Small pieces of the leaves of legumes were infected with tick eggs, and then sprayed with aqueous dispersions of the studied products (see Table 5). The mortality rate was determined after b days after treatment (untreated leaves, mortality 0),
    7) Biological effect on Spodoptera jittoralis (lepidoptera).
    The cut tobacco leaves were sprayed with aqueous dispersions of the products studied (see Tables 4 and 5).
    After drying, the leaves were infected with five daily larvae. The percentage of mortality of the larvae was determined 48 h after treatment (untreated leaves, mortality. 0).
    8) Biological effect on Meloidogyne nicognita (nematode).
    A mixture of soil and sand, 1: 1, contaminated with newly grown caterpillars and nematode eggs, was treated with aqueous dispersions of the studied products, mixing the latter with the mixture (see Table 4, and 5). Then the primer was placed in plastic; After 5 days, 5 popped tomato seedlings, about 20 cm high, were planted in each pot.
    Results were evaluated 21 days after planting. The roots of plants extracted from the soil were evaluated by the degree of charge on the basis of the number of galloids formed.
    The nematocidal effect was expressed as a percentage decrease in charge compared with control samples (small seedlings planted in untreated soil, activity 0).
    9) Biological effect on Ni1emylabrassisae (Diptera).
    Small portions of the soil were treated with aqueous dispersions of the studied compounds by uniformly mixing the latter with the soil (see Tables 4 and 5). Then the soil was placed in. two pots, in each of which planted. 4 seeds of radish. Then
    the plants were infected by placing 50 Diptera larvae in the ground in the middle of the surface of the pots.
    Results were evaluated 10 days after treatment by removing the plants from the soil and counting the number of larvae in the roots and in the surrounding soil. .
    Insecticidal activity was expressed as a percentage reduction in infection compared to control samples (plants planted in untreated soil, activity 0).
    10) Biological effect on Blatta oriental s (spraying).
    The bottom and walls of the glass crystallizer were treated with an acetone-1M solution of the test products (see Tables 4 and 5).
    After evaporation of the solvent, ten 80-100 day old larvae were placed in each crystallizer. Then the molds were closed with metal sets. 24 hours after the treatment, the insects were placed in untreated crystallizers,. where they were grown. The percentage of mortality (untreated insects 0) was determined 48 hours after the start of treatment.
    1,2,4-Triazole-5 rny
    The continuation of the table.1.
    X) Melting points not corrected.
    dp
    I (U
    HD
    aEH
    about tn
    about
    0) and
    1L
    a; in
    so
    0k
    A oi
    § "
    - and ttl) X
    ABOUT "
    v
    about about with H "e
    ok
    m oo
    about w and oi x
    I "j flj a c (P
    go
    “G.
    tt u
    and
    about
    x f

    X
    l
    to
    | in
    (I) n)
    eight
    s
    .
    R |
    ; "
    about
    &
    with a
    CJ
    + +
    1 t
    +
    +
    +
    + +
    +1
    + 1
    + +
    + +
    + 1
    +
    +
    +
    +
    + + +
    + (+ +. +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    +
    + +
    + 1 +
    +
    +
    +
    +
    + +
    + +
    GM
    Ov
    rH
    “00
    +
    4+
    +
    +
    27
    权利要求:
    Claims (2)
    [1]
    1. The patent of FRG 2260015, cl. C 07 F 9/65, published 1973.
    [2]
    2. US patent number 36689500, cl. 260-308, published. 1972.
    类似技术:
    公开号 | 公开日 | 专利标题
    RU2037488C1|1995-06-19|Derivatives of 3-cyano-5-alkoxy-1-arylpyrazole and composition on their basis
    US4012506A|1977-03-15|Pyrimidyl thio- and dithio-phosphoric acid esters
    SU795485A3|1981-01-07|Method of preparing triazole-containing thiophosphoric acid esters
    CA1177081A|1984-10-30|Pyrazol-4-yl phosphates
    US3422190A|1969-01-14|Aromatic isonitrile pest controlling agents
    CA1076585A|1980-04-29|Phosphoric acid derivatives
    US4256902A|1981-03-17|Process for the preparation of 3-chloro-5-hydroxypyrazoles
    US3948935A|1976-04-06|Pyrazoline derivatives
    US4209512A|1980-06-24|Mono- and di-thiophosphate esters containing an isoxazolinone ring and compositions and methods containing the same
    US5134133A|1992-07-28|Oxime phosphate pesticidal compounds, compositions and methods
    CA1064490A|1979-10-16|Imidazole derivatives
    US4560682A|1985-12-24|Organophosphoric acid esters of benzofuranols and pesticidal compositions thereof
    US3847936A|1974-11-12|O,o-dialkyl-o-|-thionophosphates
    CA1225650A|1987-08-18|Insecticidal carbamates
    CA1106387A|1981-08-04|1,2,4-triazole intermediate derivatives
    CA1101863A|1981-05-26|O-[4,6-dimethyl-5-alkoxycarbonyl-pyridine-|-yl]- phosphate compounds
    AU622653B2|1992-04-16|1-dimethylcarbamoyl-3-substituted-5-substituted-1h-1,2,4- triazoles
    KR800001183B1|1980-10-20|Process for 1,2,4-triazole phosphoric esters
    US4015974A|1977-04-05|Amido phosphorothiolates
    US3220922A|1965-11-30|Amino-triazol derivatives
    US4499098A|1985-02-12|Insecticidal N-carbamoyl-oxadiazolidin-5-ones and thiones
    US3475452A|1969-10-28|Phosphates and phosphonates of cyclic sulfones
    US3755512A|1973-08-28|3-dialkoxyphosphorylthio-acrylamides and related compounds
    US3824268A|1974-07-16|Perhalocoumalin derivatives
    IL41505A|1976-02-29|Thiazolymethylthio|phosphoric and thio-|phosphonic acid esters as insecticidal compounds of low mammalian toxicity
    同族专利:
    公开号 | 公开日
    AU3066477A|1979-05-24|
    JPS5363380A|1978-06-06|
    AR224612A1|1981-12-30|
    FR2379527B1|1982-07-30|
    EG12811A|1979-12-31|
    DD135030A5|1979-04-11|
    OA05803A|1981-05-31|
    CA1095058A|1981-02-03|
    DK501077A|1978-05-18|
    US4400517A|1983-08-23|
    NL7712430A|1978-05-19|
    FR2379543A1|1978-09-01|
    AU516865B2|1981-06-25|
    US4220789A|1980-09-02|
    DD132664A5|1978-10-18|
    KE3138A|1981-07-24|
    CH640541A5|1984-01-13|
    FR2379527A1|1978-09-01|
    LU78528A1|1978-07-14|
    IL53390D0|1978-01-31|
    GR71997B|1983-08-26|
    FR2379543B1|1982-03-05|
    BR7707633A|1978-06-13|
    PT67279B|1979-04-19|
    IL53390A|1982-03-31|
    JPH0134996B2|1989-07-21|
    NO773853L|1978-05-19|
    ES464206A1|1978-07-16|
    PT67279A|1977-12-01|
    IN148991B|1981-08-08|
    GB1576964A|1980-10-15|
    DE2750813A1|1978-05-18|
    RO75961A|1981-03-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE805763C|1949-02-10|1951-05-28|Dr Heinz Gehlen|Process for the preparation of 1,2,4-triazolonen- substituted on the carbon atom|
    BE637016A|1951-04-20|1900-01-01|
    DE1235930B|1963-10-15|1967-03-09|Acraf|Process for the preparation of 1-phenyl-3-butyl-4-methyl-triazolon- suitable as a medicinal product|
    CH523017A|1969-11-21|1972-05-31|Agripat Sa|Pesticides|
    DE2150169A1|1970-10-22|1972-04-27|Agripat Sa|New esters|
    BE792450A|1971-12-10|1973-06-08|Ciba Geigy|ORGANOPHOSPHORUS COMPOUNDS AND PESTICIDAL PRODUCTS WHICH CONTAIN IT|
    BE792452A|1971-12-10|1973-06-08|Ciba Geigy|TRIAZOLYL ESTERS OF PHOSPHORUS ACIDS AND PESTICIDE PRODUCTS CONTAINING|
    IT998314B|1973-08-02|1976-01-20|Montedison Spa|ALPHA ALCHYL MERCAPTO ALPHA SUBSTITUTE YOU FORMYLIDENE PHENYL HYDRAZINS ACTIVE INTO AGAINST FUNGAL DISEASES OF PLANTS|
    DK501077A|1976-11-17|1978-05-18|Montedison Spa|NEW PHOSPHORIC ACID RESIDENTS DERIVED FROM 1,2,4-TRIAZOLE WITH INSECTICIDE NEMATODICIDE AND ACARICID EFFECT AND METHOD OF MANUFACTURE|DK501077A|1976-11-17|1978-05-18|Montedison Spa|NEW PHOSPHORIC ACID RESIDENTS DERIVED FROM 1,2,4-TRIAZOLE WITH INSECTICIDE NEMATODICIDE AND ACARICID EFFECT AND METHOD OF MANUFACTURE|
    DE3931303A1|1989-09-20|1991-03-28|Desowag Materialschutz Gmbh|PROCESS FOR PREVENTIVE MATERIAL PROTECTION AGAINST TEMPORARY AND / OR TEMPORARY GROUND LIFE, IN PARTICULAR TERMITES|
    JPH06279421A|1993-03-24|1994-10-04|Nippon Paint Co Ltd|New triazole compound, intermediate therefor and its synthesis|
    US5728834A|1996-11-14|1998-03-17|Wyckoff Chemical Company, Inc.|Process for preparation of 4-aryl-1,2,4-triazol-3-ones|
    DE19823131A1|1998-05-23|1999-11-25|Bayer Ag|New sulfonylaminocarbonyl-triazolinone derivatives, used as herbicides or as fungicides or bactericides for plant protection|
    US6492527B1|1999-10-13|2002-12-10|Fmc Corporation|Process to prepare aryltriazolinones and novel intermediates thereto|
    BR0315247A|2002-10-11|2005-08-30|Cytokinetics Inc|Composition, pharmaceutical composition, method of treatment for a cell proliferative disease, and kit|
    CN101643451B|2008-08-07|2013-03-06|浙江海正药业股份有限公司|Peroxisome proliferator-activated receptor subtype delta agonist compound and preparation method thereof|
    CA2742317A1|2008-11-06|2010-05-14|Schering Corporation|Gamma secretase modulators|
    CN106543139B|2015-09-17|2020-03-17|沈阳中化农药化工研发有限公司|Triazolone compound and application thereof|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    IT29420/76A|IT1068010B|1976-11-17|1976-11-17|NEW PHOSPHORIC ESTERS DERIVED FROM 1-2-4 TRIAZOLE WITH INSECTICIDE, NEMATOCIDE AND ACARICIDE ACTION AND THEIR PREPARATION|
    IT2085577A|IT1113760B|1977-03-03|1977-03-03|1,2,4-Triazolyl--phosphate insecticides and acaricides - prepd. e.g. by cyclisation of a -semicarbazone then reacting with a O,O-di:alkyl--phosphoryl chloride |
    [返回顶部]